Plasma free hemoglobin and microcirculatory response to fresh or old blood transfusions in sepsis.
Free hemoglobin (fHb) may induce vasoconstriction by scavenging nitric oxide.It may increase in older blood units due to storage lesions.This study evaluated whether old red blood cell transfusion increases plasma fHb in sepsis and how the microvascular response may be affected.This is a secondary analysis of a randomized study.Twenty adult septic